Everyone shares the universal circumstance of having been born, but social location and material culture shape each experience of human reproduction. Contraceptives, breast pumps, hospital wards, and more have long been taboo, underresearched, and excluded from means of cultural dissemination in architecture and design history and practice. The Designing Motherhood book, exhibition, programs, and curriculum are critical reappraisals of the objects and systems that shape such experiences today. The project stems from the US, a country ranked last worldwide for paid family leave provisions, where reproductive health is a political debate rather than a personal choice, and where maternal mortality has doubled since 1991. No other project like this exists. By shifting our understanding of architecture and design, Designing Motherhood acts as a prompt for future scholars, curators, architects, designers, and audiences to take up this urgent call to action.